Five-term incumbent Republican Jim Inhofe had been re-elected with 63% of the vote in 2020, and was not scheduled to be up for election again until 2026. However, Inhofe announced his intention to resign at the end of the 117th Congress. A special election to fill his seat will take place in November 2022, concurrent with the other Senate elections. U.S. Representative Markwayne Mullin, and former Oklahoma House Speaker T. W. Shannon are competing in the runoff Republican primary election. Mullin and Shannon defeated Inhofe’s chief of staff Luke Holland and others in the initial Republican primary election.

Additionally, former U.S. Representative Kendra Horn is the Democratic nominee, being her party’s only candidate.

Source: Wikipedia